Welcome to the Higgins Lab

Imperial College London
DEPARTMENT OF BIOENGINEERING

Wang ECE, Higgins CA. 2020, Immune cell regulation of the hair cycle. Exp Dermatol. 29(3):322-333. doi: 10.1111/exd.14070.

Boyle CJ, Carpanen D, Pandelani T, Higgins CA, Masen MA, Masouros SD. 2020, Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers. PLoS One. 15(1):e0227064. doi: 10.1371/journal.pone.0227064.

Topouzi H, Boyle CJ, Williams G, Higgins CA. 2019, Harnessing the Secretome of Hair Follicle Fibroblasts to Accelerate Ex Vivo Healing of Human Skin Wounds. J Invest Dermatol. pii: S0022-202X(19)33375-5. doi: 10.1016/j.jid.2019.09.019.

Boyle CJ, Plotczyk M, Villalta SF, Patel S, Hettiaratchy S, Masouros SD, Masen MA, Higgins CA. 2019, Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load. Sci Adv. 5(10):eaay0244. doi: 10.1126/sciadv.aay0244.

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S. 2019, Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid. ACS Nano. 13(8):9620-9628. doi: 10.1021/acsnano.9b04783.

Logan NJ, Camman M, Williams G, Higgins CA. 2018, Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model. Bone. 117:149-160. doi: 10.1016/j.bone.2018.09.008.

Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT, Higgins CA. 2018, Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic. Br J Dermatol. 179(2):381-393. doi: 10.1111/bjd.16255.

Pantelireis N, Higgins CA. 2018, A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth. Exp Dermatol. 27(9):959-965. doi: 10.1111/exd.13690.

Kiani M, Higgins CA, Almquist, BD. 2018, The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine, ACS Biomater. Sci. Eng. Apr 9;4(4):1193-1207. doi: 10.1021/acsbiomaterials.7b00072.

Liu J, Higgins CA, Whitehouse JC, Harris SJ, Crawford H, Christiano AM, Lako M, Hole N, Jahoda CAB. 2018, Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures. Stem Cells Int. 8631432. doi: 10.1155/2018/8631432. eCollection 2018.

Topouzi H, Logan NJ, Williams G, Higgins CA. 2017, Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles. Exp Dermatol. 26(6):491-496. doi: 10.1111/exd.13368. Review.

Higgins CA, Roger M, Hill R, Ali-Khan AS, Garlick J, Christiano AM, Jahoda CA. 2017, Multifaceted role of hair follicle dermal cells in bioengineered skins. Br J Dermatol. doi: 10.1111/bjd.15087.

Logan NJ, Arora H, Higgins CA. 2017, Evaluating Primary Blast Effects In Vitro. J Vis Exp. 18;(127). doi: 10.3791/55618.

Topouzi H, Higgins CA. 2016, Changing faces: Can a new identity stop balding?, Exp Dermatol, Vol: 25(10), Pages: 765-766

Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AM. 2015, Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells, PLos ONE, Vol: 10(8):e0136713.

Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AM. 2015, Pharmacologic inhibition of JAK-STAT signaling promotes hair growth., Sci Adv, Oct 23;1(9):e1500973

Furniss M, Higgins CA, Martinez-Mir A, Horev L, Petukhova L, Stanimirovic A, Miljkovic J, Zlotogorski A, Christiano AM. 2014, Identification of Distinct Mutations in AAGAB in Families with Type 1 Punctate Palmoplantar Keratoderma, J Invest Dermatol, Vol: 134, Pages: 1749-1752

Higgins CA. 2014, Interrogating the integument: the role of the epidermis in hair induction, Exp Dermatol, Vol: 23, Pages: 714-715

Higgins CA, Christiano AM. 2014, Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia, Regen Med, Vol: 9, Pages: 101-111

Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AM. 2014, FGF5 is a crucial regulator of hair length in humans, PNAS, Vol: 111, Pages: 10648-10653

Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes R. 2014, Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition, Nat Med, Vol: 20, Pages: 1043-1049

Bhogal RK, Mouser PE, Higgins CA, Turner GA. 2014, Protease activity, localization and inhibition in the human hair follicle. Int J Cosmet Sci. 36(1):46-53. doi: 10.1111/ics.12091.

Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AM. 2013, Building a microphysiological skin model from induced pluripotent stem cells, Stem Cell Res Ther, Vol: 4 Suppl 1:S2

Higgins CA, Chen JC, Cerise JE, Jahoda CAB, Christiano AM. 2013, Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth, PNAS, Vol: 110, Pages: 19679-19688

Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AM. 2013, Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs), PLos ONE, Oct 11;8(10):e77673.

Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CAB, Christiano AM. 2012, Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells, J Invest Dermatol, Vol: 132, Pages: 1725-1727

Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CAB. 2012, Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures, PLos ONE, 7(11):e50742.

Higgins CA, Westgate GE, Jahoda CAB, 2011, Modulation in Proteolytic Activity Is Identified as a Hallmark of Exogen by Transcriptional Profiling of Hair Follicles, J Invest Dermatol, Vol: 131, Pages: 2349-2357

Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CAB. 2010, Modelling the hair follicle dermal papilla using spheroid cell cultures, Exp Dermatol, Vol: 19, Pages: 546-548

Higgins CA, Richardson GD, Westgate GE, Jahoda CAB. 2009, Exogen involves gradual release of the hair club fibre in the vibrissa follicle model, Exp Dermatol, Vol: 18, Pages: 793-795

Higgins CA, Westgate GE, Jahoda CAB, 2009, From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber, J Invest Dermatol, Vol: 129, Pages: 2100-2108