Hayes, J., Higgins, CA (2024) Plantar Skin: A Callus Design? Journal of Investigative Dermatology, 144(7):1427-1429. doi: 10.1016/j.jid.2024.01.038
Logan, NJ., Broda, KL, Pantelireis, N., Williams, G., Higgins, CA (2024) Chromatin accessibility profiling reveals that human fibroblasts respond to mechanical stimulation in a cell-specific manner. JMBR Plus. 29;8(5):ziae025. doi: 10.1093/jbmrpl/ziae025.
Redmond, LC., Limbu, S., Farjo, B., Messenger, AG., Higgins, CA. (2023) Male pattern hair loss: Can developmental origins explain the pattern? Experimental Dermatology 32 (7), 1174-1181. doi.org/10.1111/exd.14839
Agramunt, J., Parke, B., Mena, S., Ubels, V., Jimenez, F., Williams, G., Rhodes, ADY., Limbu, S., Hexter, M., Knight, L., Hashemi, P., Kozlov, AS., Higgins, CA (2023) Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons. Science Advances. doi 10.1126/sciadv.adh3273
Plotczyk, M., Jimenez, F., Limbu, S., Boyle, CJ., Ovia, J., Almquist, BA., Higgins, CA (2023) Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue. Nature Regenerative Medicine. doi: 10.1038/s41536-022-00270-3
Higgins, CA., Jahoda, CAB (2022) Historical studies underpinning follicle neogenesis in Hair Follicle Regeneration (Edition 1), edited by Claire Higgins & Francesco Jimenez, Springer Nature Publishing.
Forneris Crego, AL., Therianou, A., Hashemi, P., Higgins CA. (2022) A catena between psychiatric disorders and non‐scarring alopecias-A systematic review. Skin Health and Disease. 2022:e194. doi: 10.1002/ski2.194
Contessi-Negrinia, N., Angelova-Volponib, A., Higgins, CA., Sharpe, PT., Celiz, AD. (2021) Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration, Materials Today Bio, https://doi.org/10.1016/j.mtbio.2021.100107
Stewart, SK., Tenenbaum, O., Higgins CA., Masouros, S., Ramasamy, A. (2020) Fracture union rates across a century of war: a systematic review of the literature. BMJ Military Health
Stewart, S., Darwood, A., Masouros, A., Higgins, CA., Ramasamy, A. (2020) Mechanotransduction in osteogenesis: current concepts and therapeutic applications. Bone and Joint Research. 9(1):1-14. doi: 10.1302/2046-3758.91.BJR-2019-0043.R2
Wang, ECE., Higgins, CA. (2020) Immune cell regulation of the hair cycle, Experimental Dermatology, 29(3):322-333. doi: 10.1111/exd.14070.
Boyle, CJ., Carpanen, C., Pandelani, T., Higgins, CA., Masen, MA., Masouros, SD (2020) Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers. PLoS One. 15(1):e0227064. doi: 10.1371/journal.pone.0227064.
Topouzi, H., Boyle, CJ., Williams, G., Higgins, CA (2020) Harnessing the secretome of hair follicle fibroblasts to accelerate wound healing in human skin. Journal of Investigative Dermatology. 140(5):1075-1084.e11 doi: 10.1016/j.jid.2019.09.019.
Limbu, S., Higgins, CA. (2019) Isolating Dermal Papilla Cells from Human Hair Follicles using Microdissection and Enzyme Digestion in Molecular Dermatology: Methods and Protocols (Edition 2), edited by Natasha Botchkareva & Gillian Westgate, Springer Publishing.
Plotczyk, M., Higgins, CA (2019) Skin Biology (Chapter 1) in Biomaterials for Skin Repair and Regeneration Edition 1, edited by Elena Garcia-Gareta, Elsevier Publishing.
Boyle, CJ., Plotczyk, M., Fayos Villata, S., Patel, S., Hettiaratchy, S.,Masouros, SD., Masen, MA., Higgins, CA (2019) Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load. Science Advances. Vol. 5, no. 10, eaay0244 doi: 10.1126/sciadv.aay0244
Al Sulaiman, D., Chang, JYH.,Bennett, NR., Topouzi, H., Higgins, CA., Irvine, JR., Ladame, S (2019) Hydrogel-coated microneedle arrays for minimally-invasive sampling and sensing of specific circulating nucleic acids from skin interstitial fluid. ACS Nano. 13(8):9620-9628. doi: 10.1021/acsnano.9b04783.
Pantelireis, N., Higgins, CA (2018) A Bald Statement - Current Approaches to Manipulate Miniaturisation Focus only on Promoting Hair Growth. Experimental Dermatology, doi: 10.1111/exd.13690
Logan NJ, Camman M, Williams G, Higgins CA. (2018) Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model. Bone. 117:149-160. doi: 10.1016/j.bone.2018.09.008.
Liu J*., Higgins, CA*., Whitehouse, C., Harris, S., Crawford, H., Christiano, AM., Lako, M., Hole, N., Jahoda, CA., (2018) Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells, and Promote Haematopoiesis in Mouse Cultures. Stem Cells International, Aug 2;2018:8631432. doi: 10.1155/2018/8631432. eCollection 2018.
*These authors contributed equally to the study.
Ghetti, M., Topouzi, H., Theocharidis, G., Papa, V., Williams, G., Bondioli, E., Cenacchia, G., Connelly, JT., Higgins, CA (2018) Sub-Populations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Skin Tissue Engineering. British Journal of Dermatology, doi: 10.1111/bjd.16255
Kiani, M., Higgins, CA*., Almquist, B* (2017) The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine. ACS Biomaterials Science & Engineering, doi: 10.1021/acsbiomaterials.7b00072
*Co-corresponding authors
Topouzi H., Logan, NK., Williams, G., Higgins, CA (2017) Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles. Experimental Dermatology, doi: 10.1111/exd.13368.
Logan, NJ., Arora, H., Higgins, CA (2017) Evaluating Primary Blast Effects In Vitro. Journal of Visualized Effects, (127). doi: 10.3791/55618.
Topouzi, H., Higgins, CA. (2016) Changing faces: Can a new identity stop balding? Experimental Dermatology, doi: 10.1111/exd.13094.
Higgins, CA., Roger M., Hill, R., Ali-Khan, AK., Garlick, G., Christiano, AM., Jahoda, CAB (2016) Multifaceted role of hair follicle dermal cells in bioengineered skins. British Journal of Dermatology, doi: 10.1111/bjd.15087.
Harel, S., Higgins, CA., Cerise, J., Dai, Z., Chen, JC., Clynes, R., Christiano, AM (2015) Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth. Science Advances, Vol. 1, no. 9, e1500973. doi: 10.1126/sciadv.1500973
Gledhill, K, Guo, Z., Umegaki, N., Higgins, CA., Itoh, M., Christiano, AM (2015) Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells, PLoS ONE, 10(8):e0136713. doi: 10.1371/journal.pone.0136713. eCollection 2015.
Xing, L*., Dai, Z*., Jabbari, A*., Cerise, J., Higgins, CA., Gong, W., de Jong, A., Harel, S., De Stefano, G., Rothman, L., Singh, P., Petukhova, L., Mackay-Wiggan, J., Christiano, AM., Clynes, R (2014) Cellular Identity of Cytotoxic T Lymphocytes in Alopecia Areata defines a therapeutic strategy focused on the IL-15 pathway and its downstream effector kinases. Nature Medicine, 20(9):1043-9. doi: 10.1038/nm.3645.
*These authors contributed equally to the study.
Higgins, CA., (2014) Interrogating the Integument: the role of the epidermis in hair induction. Experimental Dermatology, 23(10), 714-715
Eungdamrong NJ., Higgins, CA., Guo, Z., Lee, WH., Gillette, Sia, SK., Christiano, AM (2014) Challenges and promises in modeling dermatologic disorders with bioengineered skin. Experimental Biology and Medicine, 239(9):1215-24.
Higgins, CA., Christiano, AM. (2014). Regenerative medicine and hair loss: future treatment options based on recent scientific developments for the culture of hair follicles. Regenerative Medicine, 9(1):101-111.
Higgins, CA*., Petukhova, L*., Harel, S., Ho, YY., Drill, E., Shapiro, L., Wajid, M., Christiano, AM., (2014) Identification of FGF5 as a crucial regulator of hair length in humans. PNAS, 111(29):10648-10653.
*These authors contributed equally to the study.
Furniss, M*., Higgins, CA*., Martinez-Mir, A., Horev, L., Petukhova, L., Stanimirović, A., Miljković, J., Zlotogorski, A., Christiano, AM., (2014) Identification of distinct mutations in AAGAB in families with Type 1 Punctate Palmoplantar Keratoderma. Journal of Investigative Dermatology, 134(6):1749-1752.
*These authors contributed equally to the study.
Higgins, CA., Chen, JC., Cerise, JE., Jahoda, CAB., Christiano, AM. (2013) Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair follicle growth. PNAS, 110(49):19679-19688 (Cover article).
Itoh, M., Umegaki, N., Guo, Z., Liu, L., Higgins, CA., Christiano, AM. (2013) Generation of 3D Skin Equivalents Fully Reconstituted from Human induced Pluripotent Stem Cells (iPSCs). PLoS ONE, 8(10):e77673.
Guo, Z., Higgins, CA., Gillette, BM., Itoh, M., Umegaki, N., Gledhill, K., Sia, SK., Christiano, AM. (2013). Building a microphysiological skin model from induced pluripotent stem cells. Stem Cell Research & Therapy, 4(Suppl 1):S2. doi: 10.1186/scrt363.
Bhogal, RK., Mouser, PE., Higgins, CA., Turner, GA. (2013) Protease Activity, Localisation & Inhibition In The Human Hair Follicle. International Journal of Cosmetic Science, DOI: 10.1111/ics.12091.
De Berker, D., Higgins, C., Jahoda, C., Christiano, A, (2012) Biology of Hair and Nails (Chapter 68) in Dermatology 3rd edition (Dermatology 3E), edited by Jean Bolognia, Joseph Jorizzo and Julie Schaffer, Elsevier Publishing.
Hill, RP., Gledhill, K., Gardner, A, Higgins, CA., Crawford, H., Lawrence C., Hutchison, CJ., Owens, WA., Kara, B., James, SE., Jahoda, CAB. (2012) Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures. PLoS ONE, 7(11):e50742.
Higgins, CA., Itoh, M., Inoue, K., Richardson, GD., Jahoda, CAB., Christiano, AM. (2012) Reprogramming of human hair follicle dermal papilla cells into induced pluripotent stem cells. Journal of Investigative Dermatology, 132:1725-1727.
Higgins, CA., Westgate, GE., Jahoda, CAB. (2011) Modulation in proteolytic activity is identified as a hallmark of exogen by transcriptional profiling of hair follicles. Journal of Investigative Dermatology, 131:2349-2537.
Higgins, CA., Richardson, GD., Ferdinando, D., Westgate, GE., Jahoda, CAB. (2010) Modelling the hair follicle dermal papilla using spheroid cell cultures. Experimental Dermatology, 19:546-548.
Higgins, CA., Westgate, GE., Jahoda, CAB. (2009) From Telogen to Exogen: Mechanisms underlying formation and subsequent loss of the hair club fibre. Journal of Investigative Dermatology, 129:2100–2108.
Higgins, CA., Richardson, GD., Westgate, GE., Jahoda, CAB. (2009) Exogen involves gradual release of the hair club fibre in the vibrissa follicle model. Experimental Dermatology, 18:793-795.